Corneal Damage & Corneal Wound Healing Models

APPLICATION:

Corneal wound healing delay
Neurotrophic keratitis
Corneal fibrosis syndrome
Persistent corneal epithelial defect (PCED)

PRECLINICAL EFFICACY MODELS:

Surface damage: corneal epithelium debridement induced by mechanical means
Depth damage: manual superficial keratectomy

EVALUATIONS:

Corneal re-epithelialization (fluorescein test, image analysis)
Corneal fibrosis (histology analysis)
Corneal anatomy (confocal microscopy)

PUBLICATIONS:

Safety and tolerability of overdosed artificial tears by abraded rabbit corneas. DAULL P et al. J. Ocul. Pharmacol. Ther. 2018; DOI: 10.1089/jop.2018.0040 Abstract

Comparison of CKC- and BAK-cationic emulsions in a rat model of corneal wound healing. DAULL P et al. EVER meeting 2015; Nice – France. Poster T034 Abstract

Comparison of the anti-inflammatory effects of artificial tears in a rat model of corneal scraping. DAULL P et al. J. Ocul. Pharmacol. Ther. 2016; DOI: 10.1089/jop.2015.0054 Article

Ocular surface effects of antiglaucoma combination therapies in a rat model of corneal scraping. DAULL P et al. EVER meeting 2012; Nice - France. Poster T037 Abstract

Ocular bioavailability of ganciclovir gel, an anti-herpetic formulation, after topical administration to intact or removed corneal epithelium of rabbit eyes. KHOSRAVI E et al. ARVO meeting 1996; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 1996; 37: S81, abstract No. 383.

Ocular pharmacokinetics of topically-applied ganciclovir in rabbits with intact or removed corneal epithelium. CHIBRET H et al. ARVO meeting 1993; Sarasota, FL - USA. Invest. Ophthalmol. Vis. Sci. 1993; 34: 1050, abstract No. 1712.

Pharmacokinetic and autoradiographic studies of basic fibroblast growth factor on de-epithelialised and intact rabbit eye. FREDJ-REYGROBELLET D et al. Curr. Eye Res.1989; 8: 1141-1152.