Early in the preclinical development process, the ophthalmology experts at Iris Pharma help clients determine the most effective direction for future studies. This may include identifying compounds that can be optimized, selecting approved drugs that can be repurposed for other uses, or optimizing an existing drug’s formulation to ensure that it is delivered successfully to a target site.
For these purposes, Iris Pharma performs pilot studies and proof of concept (POC) efficacy experiments in validated animal models to investigate in vivo pharmacology, pharmacokinetics (PK), ocular tolerance, and safety. These prospective studies have a simplified study design with a limited number of animals per group, so fewer resources are required before proceeding with more advanced studies.
